Posts by Patricia de Vries

Sudden onset salivary and lacrimal gland dysfunction induced by immune checkpoint inhibitors The present report details the clinical presentation of a patient with sudden-onset oral and ocular dryness secondary therapy with immune checkpoint inhibitors. A 72-year-old female was referred by an oncology team to Oral Medicine in UCLHT Eastman Dental Hospital for investigation and management…

Introduction: Previously we developed a tissue-engineered in vitro model of T-cell-mediated oral mucocutaneous inflammatory conditions, such as oral lichen planus (OLP) and validated this against human biopsy tissue. Here, we use this new model to examine the efficacy of small molecule inhibitors (e.g., JAK, KCa3.1 channels) for their potential treatment of OLP. Materials and Methods:…

Background: Medication-related osteonecrosis of the jaws (MRONJ) is an irreversible and potentially severe adverse effect to anti-resorptive and antiangiogenic medications. It manifests as areas of necrosis to the jawbones, often associated with facial disfigurement, pain, persistent infection, and impaired oral functions including speaking and eating. Treatment of MRONJ is challenging and typically burdened by unpredictable…

Authors: A Khan, S Joshi, H McParland, M Ormond, J Davies. A case of multi-cystic parotids. Approximately 80% of patients with Sjogren disease experience parotid gland enlargement, however parotid cysts are rare1. A 59-year-old female presented with bilateral parotid gland swelling, lethargy and dry eyes. Investigations revealed positive anti-SSRo52/Ro60 antibodies, ANA 1/80 and positive Rheumatoid…

The present report details the diagnostic investigation and management of a patient with oncocytoma of a parotid gland. A 52-year-old male patient presented to Oral Medicine in UCLH Eastman Dental Hospital, with a history of a generally painless solitary lump of the right parotid gland of approximately 5 years duration. There was no identifiable initiating…

Osteoradionecrosis of the jaw (ORNJ) is a severe complication of head and neck radiotherapy. It is characterized by necrotic bone that fails to heal and significantly impacts patients’ quality of life (QoL) through chronic pain, functional impairments, and aesthetic concerns. Despite its clinical significance, there is a gap in specific patient-reported outcome measures (PROMs) for…

Introduction We present the novel use of Lenalidomide in the management of a case of Major Recurrent Aphthous Stomatitis (RAS) recalcitrant to management with conventional therapies. Case A 37-year-old female presented with painful recurrent oral ulceration of 2 years duration that was managed in primary care with topical corticosteroids, which eventually became ineffective. She experienced…

Osteonecrosis of the jaw (ONJ) is a notable adverse effect linked to antiresorptive therapies used in the management of oncology and osteoporosis. This case study details a 71-year-old male patient who developed ONJ secondary to Denosumab treatment, administered as injections every four weeks over a year. The patient, evaluated at Birmingham Dental Hospital, presented with…

Background: Oral epithelial dysplasia (OED) is a histological diagnosis and is related to cellular changes within the oral epithelium that is associated with an increased risk of progression to oral cancer. Risk factors that increase the risk of malignant transformation include smoking, alcohol consumption, site and appearance of the lesion. There are currently no standardised…

Background A sixteen-year-old male was referred to the Department of Child Dental Health at University Dental Hospital of Manchester regarding erythematous lesions on the buccal gingivae. These lesions had been present for approximately eighteen months without any changes in shape or size. The patient was asymptomatic with no relevant medical history. No known cause for…