The 2021 BISOM Winter Meeting took place virtually on Thursday 18th November 2021 and was attended by 170 delegates. Our theme this year was immunobullous disease, with expert speakers providing excellent talks regarding oral, cutaneous, ocular and ENT involvement, in addition to immunofluorescence studies and use of biologic therapies. The afternoon session comprised presentations from successful abstracts, with presentations encompassing original investigation and case reports.